
Hormones and histamine intolerance
The connection between histamine and estrogen
It has been suspected for a long time thatFemale sex hormones influence the behavior of mast cells. Mast cells are cells of our immune system that release histamine if necessary. They are mainly in the gastrointestinal tract, in the skin, the breathing organges, but also in the uterus and ovaries.
Kirmaz et al. In 2004 with the help of a special skin prick test showed thatChange allergic reactions in women during menstruation. This was attributed to the hormone fluctuations during the cycle.
Estrogen and histamine release
Many studies have proven that Estrogen - especially in the form of estradiol - triggers the activation of mast cells. But estrogen not only ensures that histamine is released from the mast cells, The enzyme dao also weakens estrogenwhich breaks down histamine. The symptoms experienced vary from woman to woman.
However, most often occur:
- Regular pain
- Strong menstrual bleeding
- Headache
- Sleep disorders
- Anxiety
- Mood swings
- Pms
- Weight problems
- fatigue
- Migraine.
Migraines arise because histamine promotes the release of nitrogen oxide. Nitrogen oxide expands the blood vessels that surround the brain and thus triggers migraines
Histamine also stimulates the ovaries to produce more estrogen.
A vicious circle is created:
- Estrogen provides the histamine release
- Histamine ensures estrogen production
Takes a woman Histamine -rich food every day To themselves, they can Hormones Due to the increased estrogen level ride fast roller coaster. Even with the Taking estrogen substitutes takes the sensitivity to histamine to. The drug can even be one Trigger histamine intolerance.
Histamine and progesterone
Progesterone is another female hormone and a very important thing.
Progesterone:
- Prevents an estrogen surplus
- Ensures that Hormone equilibrium
- Inhibited the Salvation of histamine From the mast cells
Progesterone is therefore essential for a balanced hormone balance. If there is too little progesterone, the estrogen level increases and triggers the symptoms mentioned above.
Histamine and menstruation
Many women report on one Worsening of the histamine intolerance symptoms before and during the rule. Before as well as during menstruation the body ensures that the basic histamine level increases and the DAO production is reduced. This promotes the merging of the muscles of the uterus in the lower abdomen, which can be felt with abdominal cramps.
Typical symptoms can be:
- Pms
- Headache
- Regular pain
- Cramp -like abdominal pain
- Itching on the vagina
- Diarrhea
The Histamine level fluctuates according to the estrogen level. This happens during the ovulation, in the premenstrual phase and at the beginning of the rule. During this time, women react more sensitive to histamine. A strict histamine -free diet in time can alleviate the symptoms.
Histamine and pregnancy
During the Pregnancy experience women usually no histamine intolerance symptoms. It is assumed that histamine is important for the development of the embryo because of its growth -promoting properties. However, this thesis has not yet been researched. During pregnancy, the body ensures that the basic histamine level is significantly lowering to protect the unborn.
The absence of histamine intolerance symptoms during pregnancy is also attributed to the fact that the Placenta the production of the Dao (approx. From the 3rd month) by a 500 times increaset. The increased DAO level ensures that the Fetus is protected against histamine poisoning. Furthermore, the DAO protects against one Premature birth, Since histamine contractions in the uterus triggers. After birth, the histamine intolerance symptoms can reappear because the DAO works "normal" again.
Menopause
A report in the Daily Mail 2018 reports that In just 12 years, the number of allergy sufferers from 8 million to 30 million in the UK becomes. These are shocking news. But what is the reason for this? It is partly due to the increasingly older population. So it seems one Connection between the start of menopause and the beginning of allergies admit. Why is that?
During the menopause The hormone balance fluctuates. This allows it to quickly become one Estrog dominance Come because the progesterone level is lower than the estrogen level. When a woman ages, she produces less estrogen. But the progesterone level drops much faster than that of the estrogen. This leads to estrog dominance and what happens then, we already know.
There is also one Relationship between asthma and histamine. A study has shown that women who have a Hormone replacement therapy have carried out one increased risk of asthma in menopause. The art now is to keep its hormonal balance in balance in order to prevent a histamine surplus and inflammation.

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Hormones, asthma and allergic respiratory diseases
Asthma and other allergic respiratory diseases are in women From early to middle adulthood Three times as high as in men. Clinical studies have proven that the female hormones responsible for this are. The picture above actually shows very nicely how the estrogen level can be responsible for this at this time, because exactly in these years the estrogen level is highest.
The spread and illness of asthma has risen drastically in the past 30 years. A 2007 study has shown that this is on one Increased concentration of estrogen -like compounds, so -called xeno -", In the environment is due. These environmental pollutants are only slowing down and gets into our food chain. We So take up through our food and groundwater. The environmental-ecstrs Activate the mast cells And thus the distribution of histamine. Besides that Reinforce the distribution of IGE antibodies. These antibodies play a major role in the development of allergies.
What can women do
One low -histamine and low -inflammatory diet Can help that things don't get out of hand. There are some Food, The one Compensate for hormone balance naturally. These are, for example Broccoli, cauliflower and especially kale. These foods are rich in Indol-3 Carbinol and regulate the hormone balance.
Other natural hormone stabilizers are Pomegranate, chickpeas, fennel, yam root, monk pepper, coconut oil, ghee, quinoa and rice. Organic foods are better because less or no pesticides are used here. With our diet we can do a lot for our hormonal balance.
The greatest enemies for a balanced hormone balance are:
- Vitamin D deficiency
- Stimulant like nicotine and caffeine
- Too little movement
- stress
- Certain medicines
- Environmental pollutants
- Heavy metal loads
- Foods that contain hormones (be careful with meat)
- Finished products
- Fruit and vegetables with sticky surfaces (indicates pesticides)
- Too little sleep
- Lack of nutrients (lack of omega 3 fatty acids)
If you suspect a disturbed hormone balance, you can Hormone status raise a doctor. The hormonal balance can be compensated for with natural creams and food. In the worst case, the disturbed balance must be restored with medication.
Conclusion
- An imbalance in the hormone balance increases the symptoms of histamine intolerance or even triggers histamine intolerance.
- Estrogen ensures the release of histamine from the mast cells.
- Histamine in turn boosts the production of estrogen. This can lead to an estrogen surplus.
- The DAO weakens estrogen.
- Histamine intolerance symptoms can occur more before or during menstruation, ovulation and during menopause.
- Progesterone prevents estrog dominance and is an anti-histamine.
- In pregnancy, a woman does not experience histamine intolerance symptoms because the DAO is increased by a 500x.
- In the case of hormone replacement therapy and during menopause, there is an increased risk of asthma and allergic respiratory diseases.
- We take estrogen to us through environmental pollutants in our food and the groundwater.
- A low -histamine, low -inflammatory and healthy diet regulates the hormone balance.
Collapsible content
SOURCES
- Narita et al 2007 https://www.researchgate.net/publication/6440247_Environmental_Estrogens_Induce_Mast_Cell_Degranulation_and_Enhance_IgE-Mediated_Release_of_Allergic_Mediators
- Her stamines? The link between Histamine and Estrogen
https://www.mthfrsupport.com.au/her-stamine-the-link-between-histamine-and-estrogen/ - Estrogen Effects in allergy and asthma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537328/ - Zierau, O., Zenclussen, A. C., & Jensen, F. (2012). Role of sex hormones, estradiol and progesterone, in mast cell behavior. Frontiers in Immunology, 3 (169). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377947/
- Golzareh, P., Rahimi, R., Rahimikian, F., Bekhradi, R., Mehran, A. (2017). The effect of Fennel Oral Capsules on Physical Symptoms Caused by Menopause in Women. The Iranian Journal of Obstetrics, Gynecology and Infertility, 20 (9), 41-48. DOI: 10.22038/iJogi.2017.9954
- Wu, W. H., Liu, L.Y., Chung, C. J., Jou, H.J., Wang, T. A. (2005). Estrogenic Effect of Yam Ingestation in Healthy Postmenopausal Women. Journal of the American College of Nutrition. 24(4): 235-43. Retrieved from:
https://www.ncbi.nlm.nih.gov/pubmed/16093400

From those affected for those affected
We are Thomas and Michaela Zinser, founder of Histaminikus.
Because of the own histamine intolerance of Michaela and our son, we founded Histaminikus. The frustration does not find any suitable histamine food has spurred us to develop low -histamine food.
We would like to give you back a piece of quality of life. Feel free to look around with us.
Kind regards
Thomas and Michaela