Influence of genetics on histamine intolerance

6 general genes that influence histamine intolerance

The six most common genes associated with histamine intolerance include:

1. Diaminoxidase (dao)
The DAO gene plays a crucial role in the production of the enzyme dao, which reduces histamine in the digestive tract. The DAO mainly metabolizes histamine from food to prevent its accumulation in the intestine and the occurrence of symptoms. Variations or mutations in the DAO gene can affect the production or activity of the DAO enzyme, which leads to a disturbed histamine mining. This enriches histamine in the body and symptoms of histamine intolerance can arise.

Typical symptoms, especially after eating histamine -rich foods:

• Headache
• migraine
• Digestion problems, nausea
• Skin problems
• Flush
• Allergy -like reactions

2. Histamine N-methyltransferase (Hnmt)
The HNMT gene is responsible for the enzyme. This enzyme mainly reduces the body's own histamine. Variations or mutations in the HNMT gene can affect the activity or expression of the HNMT enzyme and impair the efficiency of the histamine metabolism. This leads to a reduced histamine mining and increased histamine values ​​in the body.

Typical symptoms:

• Headache
• clogged nose
• Rashes, atopic dermatitis
• asthma
• Gastrointestinal problems
• Unrest, sleep disorders, fatigue
• Dizziness, anxiety
• Allergy -like reactions

3. Histidin decarboxylase (HDC)
The HDC gene plays a crucial role in the production of histamine in the body. The HDC gene provides instructions for the production of the enzyme histidind carboxylase, which converts the amino acid histidine into histamine. Variations or mutations in the HDC gene can affect the activity or expression of the enzyme Histidind carboxylase, which leads to changes in histamine production. This can lead to an unbalanced histamine level that contributes to the symptoms of histamine intolerance.

If the HDC gene is affected, it can increase or reduce histamine production depending on the specific variation. A higher histamine synthesis can lead to an excess of histamine in the body, which results in increased sensitivity to symptoms. On the other hand, lower histamine synthesis can affect the body's ability to maintain an optimal histamine level, which can also lead to histamine intolerance symptoms.


4. Methylentetetrahydrofolate reductase (MTHFR)
The MTHFR gene is not directly related to histamine intolerance. However, it plays a crucial role in a biochemical process known as methylation. The MTHFR gene provides instructions for the production of the MTHFR enzyme, the folate (vitamin B9) converts into its active form (methyl folacy). Methyl folk is an important part of the methylation process, which influences different body functions, including the metabolism and the excretion of histamine.

Impairments of the MTHFR gene can lead to reduced production or activity of the MTHFR enzyme and thus to a reduced methylation capacity. This can affect the regulation of histamine levels and contribute to symptoms. In addition, people with MTHFR genes tend to become imbalances in other methylation-related processes that can further influence histamine metabolism and histamine intolerance.


5. HRH1
You have already got to know the HRH1 gene above. This gene plays a role in determining sensitivity and reactions to histamine by controling the H1 receptor. Changed variants of the HRH1 gene can lead to an increased sensitivity or overactivation of the H1 receptor, which causes exaggerated reactions to histamine.

Typical symptoms:

• Rashes
• itching
• stuffy nose
• Breathing difficulties

6. Monoaminoxidase (MAO)
The main task of the enzyme Mao is to reduce biogenic amine such as tyramine and catecholamines. However, it can also affect the histamine level in the body. A low MAO mirror can lead to a reduced breakdown of histamine, which results in high histamine concentrations in the body. This imbalance can contribute to the development or worsening of histamine intolerance symptoms. In addition, variations in the gene can also lead to fluctuations in the mirror of other biogenic amines. If biogenic amines increase next to histamine, strong symptoms could arise. In addition, biogenic amine is always broken down by the enzyme dao, so that histamine can often no longer be adequately metabolized.

Of course, genetics are not everything. It is only part of the picture. Environmental factors, nutrition, lifestyle, external influences and other diseases also play an important role in the development of histamine intolerance.

Nevertheless, it is now scientific consensus that our genetics have a great influence on our health and the development of diseases depending on the assessment. This opens up new opportunities to estimate and counteract any preventive risks for certain diseases. Especially when several family members suffer or suffered from the same diseases, genetic clarification can be useful.

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