Darm-liver axis

Have you ever heard of the intestinal liver axis? This close connection between the intestine and liver is another fascinating example of how our inner organs communicate with each other and work together for our health. In this blog post you will learn how the intestine and the liver work together and how you can optimally support both organs.

What is the intestinal liver axis?

The intestine and liver not only have a close functional connection, but even come from the same cell leaders. Together they ensure that nutrients are absorbed and processed from food. At the same time, separate the intestinal microbiome - i.e. the countless bacteria in the intestine - from the rest of the bloodstream to protect the body. Together they work to keep a balance: they ensure that the body is well supplied with nutrients, tolerate harmless bacteria and food components and at the same time offer protection against pathogens. This close cooperation is also evident in medicine, because diseases often affect not just an organ, but both at the same time.

The intestinal liver axis describes the bidirectional connection between the digestive system and the liver. Everything we consume - be it food, medication or stimulant such as alcohol - must be processed and broken down by the liver. With an impressive surface of over 200 m², the intestine is again the largest organ of humans and is closely connected to the liver. Everything that is absorbed into the blood from the intestine - including nutrients, vitamins, but also messenger substances such as cytokines and bacterial components - reaches the liver via the portal vein. This is not a problem under normal circumstances, because only a few bacterial components such as endotoxins or bacterial DNA pass the intestinal wall and are quickly made harmless in the liver.

The intestine and liver are often considered separately. However, current research projects, such as that of the CRC1382, rely on a new, holistic approach: they not only examine the functions of the two organs individually, but also consider them as a unit - including their metabolic processes, their immune defense and their interactions with the microbiome.

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So communicate intestine and liver

Your constant exchange works via various biological "lines":

  • The portal vein transports nutrient -rich blood as well as various molecules and messenger substances from the intestine directly into the liver.
  • The bile duct in turn leads products and signal fabrics from the liver to the intestine.
  • In addition, hormones, cytokines, bile acids, wandering immune cells and fabrics that are produced by intestinal bacteria ensure a close functional connection between the two organs.
  • Immunzelles in the intestine and in the liver constantly perceive signals from their surroundings and thus regulate inflammation and the balance in the entire body.

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Diseases of the intestinal liver axis

Your constant exchange works via various biological "lines":

  • The portal vein transports nutrient -rich blood as well as various molecules and messenger substances from the intestine directly into the liver.
  • The bile duct in turn leads products and signal fabrics from the liver to the intestine.
  • In addition, hormones, cytokines, bile acids, wandering immune cells and fabrics that are produced by intestinal bacteria ensure a close functional connection between the two organs.
  • Immunzelles in the intestine and in the liver constantly perceive signals from their surroundings and thus regulate inflammation and the balance in the entire body.

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Therapeutic approaches

Since the connection between the intestine and the liver is so tight, targeted treatments can be promising. Various approaches are already used in clinical practice:

  • Stool transplants for restoring a healthy intestinal flora
  • Antibiotics to influence the microbiome
  • Diet changes to improve intestinal health and relieve the liver
  • Modulation of the bile acids to regulate metabolic and inflammatory processes

Although these treatments are already used, the knowledge of the exact molecular and immunological mechanisms behind it is still limited. Research is only at the beginning-but it shows that the intestinal liver axis plays a crucial role in our health.

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Connection with allergies and intolerances

We have often described how important the liver and the intestine are for our health. This also results in the high priority of the liver and intestine in terms of histamine intolerance and other intolerances and allergies. Both organs are significantly involved in the breakdown of histamine. The metabolism and the reaction to allergens are also closely related to the intestinal liver axis. A well -functioning liver can help to dampen inflammatory processes and allergic reactions by actively involved in the processing and elimination of metabolism products.

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Tips for a healthy intestine and a strong liver

With a few simple habits you can optimally support the liver and intestine. A lot of water and unsweetened tea help to smuggle pollutants better out of the body. Sugit soft drinks and alcohol, on the other hand, put the liver and intestine under stress and ensure that you have to work unnecessarily. A healthy diet relieves our organs enormously. If you are already attacked, it is worth avoiding heavily processed foods, sugary dishes and drinks, alcohol and greasy food for a few months. In contrast, green vegetables with many bitter substances that promote our liver and digestion are particularly good for the liver.

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Liver love

Bitter substances are being deleted into our western world more and more from the nutrition plan. Bitter substances are essential for our well -being in the stomach. 

Our liver love capsules contain valuable bitter substances from 3 natural plant substances. Choline is also included that contributes to the preservation of normal liver function. The vegan capsules are easy to dose and are ideal for people who do not like the bitter taste of bitter substances. Of course, the capsules can also be opened and drunk in water.

👉🏼 To the liver love

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Everything that reaches the liver comes through the intestine. Poor nutrition, medication or permanent stress can bring the intestinal flora out of balance and make the intestinal wall more permeable. This means that more pollutants get into the liver than they can process. Here, specifically researched probiotics can help in order to positively influence the liver function through the intestine.

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The bacteria sensitive

When developing the intestinal bacteria sensitively, we have incorporated our years of experience in the field of histamine intolerance and your customer opinions. Stress, a vegan or restricted diet, infections and other special living conditions often consume more from amino acid L-glutamine than can be filled.

👉🏼 To the bacteria sensitive

Sport not only is good for the whole body, but also promotes blood flow to the liver, stimulates the metabolism and promotes intestinal engine. It does not have to be a marathon - a few hundred steps more per day or regular small movement units help noticeably.

There are some medicinal plants and natural substances that demonstrably support the liver. Artichoke, dandelion and dukes of the deaf that are rich in bitter substances and promote digestion and liver function are particularly effective. Grape seed extract contains highly effective antioxidants that neutralize free radicals. You can find more information about naturopathic liver therapy here.

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SOURCES

Thomas und Michaela Zinser, Gründer von Histaminikus, sitzen lächelnd nebeneinander auf einer Steinstufe vor einer Backsteinmauer mit Blick auf eine Landschaft. Neben ihnen stehen mehrere Histaminikus-Produkte, darunter Gewürzdosen und Papiertüten.

From those affected for those affected

We are Thomas and Michaela Zinser, founder of Histaminikus.

Because of the own histamine intolerance of Michaela and our son, we founded Histaminikus. The frustration does not find any suitable histamine food has spurred us to develop low -histamine food.
We would like to give you back a piece of quality of life. Feel free to look around with us.

Kind regards
Thomas and Michaela

Histamine -free shopping